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In 2013 between 9 and 28 million people used ecstasy recreationally (0.2% to 0.6% of the global population between the ages of 15 and ) This was broadly similar to the number for cocaine, substituted amphetamines, and opioids, but far fewer than the number of cannabis users.

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More research is needed in order to determine if its potential usefulness in posttraumatic stress disorder (PTSD) treatment outweighs the risk of persistent harm to a patient.